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El MDR-1 (Sensibilidad medicamentosa del gen mdr1)
El MDR-1 o gen de resistencia a multidrogas es el encargado de producir una proteína transportadora (P-glicoproteína) que representa una barrera funcional de protección para el cerebro contra fármacos y otras toxinas. Cuando el gen sufre mutación y no es funcional ciertas sustancias medicamentosas se acumulan en el cerebro y otros órganos como el hígado y los riñones, se vuelven tóxicas y provocan daños neurológicos, hepáticos, renales e incluso el coma y la muerte del animal. Algunas razas de perros, entre las que se encuentran la familia Collie, tienen más posibilidades de presentar la mutación. En Estados Unidos, aproximadamente tres de cada cuatro Collies poseen el gen MDR-1 mutado. La frecuencia es la misma en Francia y en Australia. La mutación de este gen también se ha detectado en Shetland, Pastor Australiano, Pastor Alemán, Bobtail… Diversos fármacos de uso habitual pueden pasar la barrera hematomeníngea en caso de deficiencia del gen MDR-1. Los más conocidos son la ivermectina (antiparasitario) y la loperamida (antidiarreico comercializado en España como Fortasec y Salvacolina). Mediante un test se puede determinar si un ejemplar posee el gen funcional, en cuyo caso se le pueden administrar estos medicamentos con normalidad, o mutado, entonces será necesario encontrar un tratamiento alternativo. Laboratorios como SLOVGEN, LABOKLIN, ANTAGENE......realizan este test genético. |
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MDR-1 (Multi drug resistance)
The MDR-1 or multidrug resistance gene is responsible for producing a transporter protein (P-glycoprotein) which represents a functional barrier protecting the brain against drugs and other toxins.
When the gene mutates and is not functional, drug substances accumulate in the brain and other organs like the liver and kidneys, they become toxic and cause neurological damage, liver, kidney and even coma and death of the animal.
Some breeds of dogs, among which are the Collie family are more likely to present the mutation. In the United States, approximately three out of four Collies have the MDR-1 gene mutation. The frequency is the same in France and Australia. The mutation of this gene has been found in Shetland, Australian Shepherd, German Shepherd, Bobtail ...
Several drugs in common use can pass the barrier for deficiency of MDR-1 gene. The best known are the Ivermectin (antiparasitic) and loperamide (antidiarrheal marketed in Spain and Salvacolina Fortasec).
Using a test can determine whether a specimen has the functional gene, in which case you can administer these medications as normal, or mutated, then you must find an alternative treatment.
Laboratories like SLOVGEN, LABOKLIN, ANTAGENE......provide this test.
Result of DNA test drug sensitivity gene status of the
genetic abnormality transmission
Homozygote normal 2 normal copies of the gene MRD1, normal doses of ivermectin, loperamide and other drugs
do not cause allergic reactions. They don´t transmit the gen to their
offspring.
Heterozygote mutant 1 defective and 1 normal copy of the gene MRD. High doses of ivermectin and normal doses of
loperamide and other drugs may be toxic. They can transmit the gen to their offspring. Statistically 50% of their offspring can carry the mutated gen.
Homozygous mutant 2 defective copies of the gene MRD1 High doses of ivermectin and normal doses of loperamide and other
drugs are highly toxic. They transmit the gen to their offspring. Statistically 100% of their offspring carry the mutated gen.
The MDR-1 or multidrug resistance gene is responsible for producing a transporter protein (P-glycoprotein) which represents a functional barrier protecting the brain against drugs and other toxins.
When the gene mutates and is not functional, drug substances accumulate in the brain and other organs like the liver and kidneys, they become toxic and cause neurological damage, liver, kidney and even coma and death of the animal.
Some breeds of dogs, among which are the Collie family are more likely to present the mutation. In the United States, approximately three out of four Collies have the MDR-1 gene mutation. The frequency is the same in France and Australia. The mutation of this gene has been found in Shetland, Australian Shepherd, German Shepherd, Bobtail ...
Several drugs in common use can pass the barrier for deficiency of MDR-1 gene. The best known are the Ivermectin (antiparasitic) and loperamide (antidiarrheal marketed in Spain and Salvacolina Fortasec).
Using a test can determine whether a specimen has the functional gene, in which case you can administer these medications as normal, or mutated, then you must find an alternative treatment.
Laboratories like SLOVGEN, LABOKLIN, ANTAGENE......provide this test.
Result of DNA test drug sensitivity gene status of the
genetic abnormality transmission
Homozygote normal 2 normal copies of the gene MRD1, normal doses of ivermectin, loperamide and other drugs
do not cause allergic reactions. They don´t transmit the gen to their
offspring.
Heterozygote mutant 1 defective and 1 normal copy of the gene MRD. High doses of ivermectin and normal doses of
loperamide and other drugs may be toxic. They can transmit the gen to their offspring. Statistically 50% of their offspring can carry the mutated gen.
Homozygous mutant 2 defective copies of the gene MRD1 High doses of ivermectin and normal doses of loperamide and other
drugs are highly toxic. They transmit the gen to their offspring. Statistically 100% of their offspring carry the mutated gen.